About us

We are a dynamic research group at the Smidt Heart Institute with Cedars-Sinai Medical Center. Our goal is to uncover underlying mechanisms that cause heart failure in cancer using interdisciplinary and computational approaches. We use systems biology approaches to measure metabolic alterations in the failing heart. Our model systems include ex vivo heart perfusions, cell cultures and in vivo mouse models. The Karlstaedt Lab has established several techniques including mathematical simulations, stable isotope tracer analysis, and mass spectrometry-based metabolomics.

Research Topics

• Cardio-Oncology
• Metabolic crosstalk between cardiac and cancer cells
• Mathematical modeling of complex biological systems
• Systems analysis of metabolism

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Collaborators

Here are some wonderful scientists that we have the honor of collaborating with.

Cedars Sinai Medical Center:

• Jennifer Van Eyk
• Roberta Gottlieb

Baylor College of Medicine:

• James F. Martin - Department of Molecular Physiology and Biophysics
• Peggy Goodell - Department of Molecular and Cellular Biology

MD Anderson Cancer Center:

• David Piwnica-Worms - Department of Cancer Systems Imaging
• Seth T. Gammon - Department of Cancer Systems Imaging
• Philip L. Lorenzi - Metabolomics Facility

University of California San Francisco:

• Roselle Abraham

UT Southwestern:

• Ralph DeBerardinis

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Please reach out if you want to collaborate with us! Contact us